You may receive an email notification of the form:

Virus/Malware: *********

Endpoint: *********

Domain: ****\********\

File: C:\*********\*********.***

Date/Time: **/**/**** **:**:**

Result: Quarantine is successful at agent, but unable to send the quarantined file to the designated quarantine folder

For agents configured to upload quarantined files to the server, the following kb describes some possible reasons:

https://success.trendmicro.com/solution/1056091-unable-to-send-the-quarantined-file-to-the-designated-quarantine-folder--appears-in-the-officescan

 
The most common reason is that the machine is off-campus/off-vpn. The edge relay only passes a small subset of information back to the server.